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COURSE DESCRIPTION

Course code: P37
Course: Acute and chronic inflammatory pancreatic disease – current approach to diagnosis, disease severity and treatment 
Course coordinator: Associate Professor Branko Papa MD, PhD
Hours - lectures: 0  
Hours - seminars: 10  
Hours - practicals: 4  
Hours - Total: 14
ECTS: 2,5
Beginning:
End:
Time:
Place: Medicinski fakultet

General and specific competencies: Competent for critical evaluation of experimental studies in acute and chronic pancreatitis. Competent to develop new diagnostic and staging algorhytms in pancreatic diseases. Competent to design a new classification of chronic pancreatitis, Competent to test this classification and the new indeces in the prospective clinical trials.
Contents: New classification of inflammatory pancreatic diseases. Current approach to etiopathogenesis of inflammatory pancreatic diseases. Development of targeting therapy. Clinical presentation-early assessment of disease severity. Rational diagnosis and treatment. Early staging of disease severity (clinical, biochemical and imaging methods). Significance of gene analysis in inflammatory pancreatic diseases. Interventional endoscopy in acute and chronic pancreatitis. Surgical treatment of inflammatory pancreatic diseases. Prevention of inflammatory pancreatic diseases. Practical work: proposal of diagnostic algorithm for acute and for chronic pancreatitis. Developing and testing new disease severity index and scores for acute pancreatitis. Application of a new classification of chronic pancreatitis. Estimating optimal time for surgery. Evaluation of published studies (Journal Club) on: 1) early antibiotic treatment in severe acute pancreatitis (pro et contra), b) early ERCP and papilotomy, c) significance of eternal nutrition in acute pancreatitis and d) onset and specifity of diabetes in chronic pancreatitis.
Co-lecturers: Prof.Miroslava Katičić MD.PhD, Prof. Elizabeta Topić PhD, Prof Petar Martinac MDPhD, Prof Miljenko Marotti MDPhD, Ass.Prof. Rajko Kušec MDPhD, Prof Izet Aganović MDPhD, Ass.Prof. Željko Krznarić MD PhD, Slavica Naumovski Mihalić MD MS
Mandatory literature: Babić Ž, Papa B, Sikirica-Bošnjaković M, Prkačin I, Mišigoj Duraković M, Katičić M. Occult gastrointestinal bleeding in rugby player. Journal of Sports Medicine and Physical Fittness 41:399-402, 2001.

Naumovski Mihalić S, Papa B, Čolić Cvrlje V, Katičić M, Prskalo M, Šabarić B, Tićak M, Šćrbec B, Škegro D, Prkačin I, Mičetić V, Škurla B. Ultrasonographic parameters-prognostic value in acute pancreatitis. Neurologia Croatica, 1999;46:161-164 .

Naumovski Mihalić S, Papa B, Prkačin I, Čolić Cvrlje V, Katičić M, Šabarić B, Šćrbec B, Cetinić N: Current management of pancreatic pseudocysts. Neurologia Croatica 2000;49.175-178.

Katičić M; Presečki V, Kalenić S; Dominis M, Filipec T; Papa B. Dijagnostika Helicobacter pylori infekcije. // Liječnički vjesnik. 124 (2002) , suppl 1; 16-20.

Papa B, Katičić M, Čolić Cvrlje V, Drinković I, Brajša M, Tićak M, Šabarić B, Naumovski S, Prskalo M: Tok i komplikacije kroničnog pankreatitisa. Gastroenteohepatološki arhiv 1989; 3:123 2).

Drinković I, Kos N, Papa B, Vidaković Z, Dolenčić P: Problemi perkutane drenaže pseudociste pankreasa iglom. U Mašković J, Boschi S, Stanić I:Intervencijska radiologija, Split 1989. str 179-182.

Naumovski Mihalić S, Papa B, Čolić Cvrlje V, Katičić M, Prskalo M, Šabarić B, Tićak M: Važnost praćenja biokemijskih i ehosonografskih parametara u ranom prepoznavanu teških oblika akutnoga pankreatitisa Zbornik radova, Prvi hrvatski gastroenterološki kongres, Zagreb, 1994.

Papa B, Katičić M,. Prskalo M, Tićak M, Čolić-Cvrlje V i sur. Complications and outcome of chronic pancreatitis-a 10-years follow up. Gut 1995:37:suppl.2.A-251.

Naumovski-Mihalic S, Papa B, Colic-Cvrlje V, Katicic M, Prskalo M, Sabaric B, Ticak M, Skurla B. Prognostic value of echonographical parameters in acute pancreatitis. Digestion 1998;59(suppl 3):489;

Papa B, Drinković I, Katicic M, Prskalo M, Čolić-Cvrlje V, Tićak M, Šabaric B, Naumovski-Mihalić S. Pancreaticoduodenal artery flow during evolution of chronic pancreatitis. Digestion 1998;59(suppl 3):503.

Papa B.: Akutni pankreatitis. U: Vucelić B. urednik. Gastroenterologija i hepatologija. Zagreb: Medicinska naklada 2002.

Papa B.: Upalne bolesti gušterače, 975-982 u Vrhovac: Interna medicina. Medicinska biblioteka Zagreb 2003.

Keck T, Werner J, Banafsche R, Klar E. Oxygen radicals promote ICAM-1 expression and microcirculatory disturbances in experimental acute pancreatitis . Pancreatology 2003;3 (2)156-63

Wittel UA, Bachem M, Siech M: Oxygen radical production precedes alcohol induced acute pancreatitis in rats. Pancreas 2003 May;26(4):E74-80

Yousaf M, Mc Callion K, Diamond T. review: Management of severe acute pancreatitis: Br J Surg 2003Apr ;90 (4):407-420

Andersson R, Andren-Sandberg A.: Fatal acute pancreatitis. Characteristics of patients never reaching hospital . Pancreatology 2003;3:64-6,

Sun B, Li HL, Gao Y, Xu J Jiang HC: Factors predisposing to severe acute pancreatitis: evaluation and prevention - World J of Gastroent
Additional reading:
Teaching forms:
Examination procedure: Test after completing the lectures. Clinical study assay (developing new classification or proposal of new scores) on the own patients or analysis of hospital data basis
Course evaluation: Internist or resident or internship in internal medicine, radiologist or resident or internship in radiology, gastroenterologist or resident or internship in gastroenterology, surgeon or resident or internship in surgery. Pediatritian or resident or

List of publications: Associate Professor Branko Papa
Babić Ž, Papa B, Sikirica-Bošnjaković M, Prkačin I, Mišigoj Duraković M, Katičić M. Occult gastrointestinal bleeding in rugby player. Journal of Sports Medicine and Physical Fittness 41:399-402, 2001.

Naumovski Mihalić S, Papa B, Čolić Cvrlje V, Katičić M, Prskalo M, Šabarić B, Tićak M, Šćrbec B, Škegro D, Prkačin I, Mičetić V, Škurla B. Ultrasonographic parameters-prognostic value in acute pancreatitis. Neurologia Croatica, 1999;46:161-164 .

Naumovski Mihalić S, Papa B, Prkačin I, Čolić Cvrlje V, Katičić M, Šabarić B, Šćrbec B, Cetinić N: Current management of pancreatic pseudocysts. Neurologia Croatica 2000;49.175-178.

4.Katičić M; Presečki V, Kalenić S; Dominis M, Filipec T; Papa B. Dijagnostika Helicobacter pylori infekcije. // Liječnički vjesnik. 124 (2002) , suppl 1; 16-20 (članak, strucni rad, professional paper).

Papa B, Katičić M, Čolić Cvrlje V, Drinković I, Brajša M, Tićak M, Šabarić B, Naumovski S, Prskalo M: Tok i komplikacije kroničnog pankreatitisa. Gastroenteohepatološki arhiv 1989; 3:123 2).

Drinković I, Kos N, Papa B, Vidaković Z, Dolenčić P: Problemi perkutane drenaže pseudociste pankreasa iglom. U Mašković J, Boschi S, Stanić I:Intervencijska radiologija, Split 1989. str 179-182

Naumovski Mihalić S, Papa B, Čolić Cvrlje V, Katičić M, Prskalo M, Šabarić B, Tićak M: Važnost praćenja biokemijskih i ehosonografskih parametara u ranom prepoznavanu teških oblika akutnoga pankreatitisa Zbornik radova, Prvi hrvatski gastroenterološki kongres, Zagreb, 1994.

Papa B, Katičić M,. Prskalo M, Tićak M, Čolić-Cvrlje V i sur. Complications and outcome of chronic pancreatitis-a 10-years follow up. Gut 1995:37:suppl.2.A-251.

Naumovski-Mihalic S, Papa B, Colic-Cvrlje V, Katicic M, Prskalo M, Sabaric B, Ticak M, Skurla B. Prognostic value of echonographical parameters in acute pancreatitis. Digestion 1998;59(suppl 3):489;

Papa B, Drinković I, Katicic M, Prskalo M, Čolić-Cvrlje V, Tićak M, Šabaric B, Naumovski-Mihalić S. Pancreaticoduodenal artery flow during evolution of chronic pancreatitis. Digestion 1998;59(suppl 3):503;



Papa B. Changes in characteristics of chronic pancreatitis during the course of disease. Coll Antropol.22 (1998)2:509-514

Papa B.: Acute pancreatitis. Personal view. International Conference on Ulcer Research ICUR 2003 g 2003.Cavtat. Book of Abstracts.

Knjige i udžbenici:

Kronični pankreatitis. Priručnik. Pliva 1987.

Upalne bolesti gušterače. Akutni i kronični pankreatitis. Hereditarni pankreatitis. Posttraumatski pankreatitis. Rak gušterače U Vrhovac i sur. Interna medicina. 1991.

Rak gušterače. U Kolarić: Klinička onkologija, 1995

Upalne bolesti gušterače. Akutni i kronični pankreatitis. Hereditarni pankreatitis. Posttraumatski pankreatitis. Rak gušterače Vrhovac i sur. Interna medicina. Naprijed Zagreb1997.

Upalne bolesti gušterače. Akutni i kronični pankreatitis. Posttraumtski pankreatitis. Str 975-982. u Vrhovac B. i sur. Interna medicina. Naklada Ljevak Zagreb 2003.

Akutni pankreatitis. U Vucelić B, urednik: Gastroenterologija i hepatologija. Medicinska naklada Zagreb 2002,. str. 961-88.

Editors

Last updated 20. October 2006.