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European Conference on Harmonisation of PhD programmes

OPIS PREDMETA

Šifra predmeta: G178
Naziv predmeta: Metabolički sindrom  
Voditeljica predmeta: prof.dr.sc. Lea Smirčić-Duvnjak izvanredni profesor
Broj sati - predavanja: 2  
Broj sati - seminari: 8  
Broj sati - vježbe: 0  
Ukupni broj sati: 10
Broj ECTS bodova: 2
Početak:
Kraj:
Vrijeme:
Mjesto: Sveučilišna klinika "V. Vrhovac"

Razvijanje općih i specifičnih kompetencija:
Sadržaj: Predavanja: metabolički sindrom: povijest, epidemiologija i patofiziologija; definicija i dijagnoza metaboličkog sindroma (metode određivanja inzulinske rezistencije)
Seminari: poremećaj metabolizma ugljikohidrata i masti u metaboličkom sindromu; metabolički sindrom i kardiovaskularne bolesti; jetrene manifestacije metaboličkog sindroma; metabolički sindrom i sindrom policističnih ovarija; metabolički sindrom i šećerna bolest tip 1; liječenje metaboličkog sindroma; najčešće dijagnostičke i terapijske dileme u metaboličkom sindromu; završni seminar (rasprava): postoji li metabolički sindrom- pro et contra?
Suradnici: Prof.dr.sc. Željko Metelko, dr.med
Prof.dr.sc. Nikica Car,dr.med
Prof dr sc. Marko Duvnjak, dr.med
Prof.dr sc. Vjeran Nikolić-Heitzler, dr.med
Literatura: Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome - a new worldwide definition. Lancet 2005;366:1059-62

Reaven GM. Insulin resistance and its consequences. In diabetes Mellitus: A fundamental and clinical text. 3rd ed. LeRoith D, Taylor SI, Olefasky JM, Eds. Philadelphia, Lippincott, Williams and Wilkins, 2004, p.899-915

Despres JP. Health consequences of visceral adiposity. Ann Med 2001;33.534-541.

Kahn R, Ferrannini E, Buse J, Stern M. The metabolic syndrome: time for a critical appraisal. Diabetes Care 2005;28;2289-304

Alberti KGMM, Zimmet PZ. Should we dump the metabolic syndrome? No. BMJ 2008;336:641-646.

Low Wang C, Goalstone ML, Draznin B. Molecular mechanisms of insulin resistance that impact cardiovacsular biology Diabetes 2004; 53(11):2735-2740.

Khan SH, Khan FA, Ijaz A, Sattar A, Dilwar M, Hashim R. Hypertension and metabolic syndrome: impact of clustering of hypertension in subjects with metabolic syndrome. Pak Med Sci 2007;23 (6);903-908.

Kjeldsen Sverre E, Naditch-Brule L, Perlini, S, Zidek W, Farsang Csaba E. Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe: the Global Cardiometabolic Risk Profile in Patients with hypertension disease survey. J Hypertens 2008; 26(10):2064-2070

Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes and cardiovascular duisease? The common soli hypothesis revisited Arterioscler Thromb Vasc Biol. 2004; 24:816-823.

Rahmouni K, Correia MLG, Haynes WG, Mark AL. Obesity-associated hypertension- new insights into mechanisms. Hypertension 2005;45:9-14

Sanjuliani AF. De Abreu VG, Francischetti EA. selective imidazoline agonist moxonidine in obese hypertensive patients. Int J Clin pract 2006;60(5):621-629.

Bakris GL. Current Perspectives on Hypertension and Metabolic Syndrome. J Manag Care Pharm 2007;13(5):S3-S5.

Medina J, Fernandez-Salazar LI, Garcia- Buey L, Moreno-Otero R. Approach to the patgogenesis and treatment of nonalcoholic steatohepatitis. Diab Care 2004; 27:2057-2066.

Boppidi H, Daram SR. Nonalcoholic fatty liver disease: hepatic manifestation of obesity and the metabolic syndrome Postgrad Med 2008; 31:120(2):E01-7.

Tsilchorozidou T, Overton C, Conway GS. The Pathophysiology of Polycystic Ovary Syndrome. Clin Endocrinol 2004; 60(1):1-17.

Bayturan O,Tuzcu ME, Lavoie A et al. The Metabolic Syndrome, Its Component Risk Factors, and Progression of Coronary Atherosclerosis Arch Intern Med. 2010;170(5):478-484. Arch Intern Med. 2010;170(5):478-484. Mente A, Yusuf S, Islam S et al. Metabolic Syndrome and Risk of Acute Myocardial Infarction A Case-Control Study of 26,903 Subjects From 52 Countries. J Am Coll Cardiol, 2010; 55:2390-2398

Simmons RK, Alberti KG, Gale EA et al. The Metabolic Syndrome: Useful Concept Or Clinical Tool? Report of a WHO Expert Consultation. F1000: "Exceptional" and "Changes Clinical Practice". Diabetologia 2010;53(4):600-5.

De Luis DA, Mongil Lopez R, Sagrado Gonzales M. Prevalence of metabolic syndrome with international diabetes federation criteria and ATP III program in patients 65 years of age or older. The Jornal of Nutrition, Health and Aging 2010; 14(5);400-404.
Dodatna literatura:
Oblici nastave:
Način provjere: završna rasprava koja uključuje kritičku analizu odabranih članaka te pismeni ispit
Uvjeti upisa:

Znanstveni radovi: prof.dr.sc. Lea Smirčić-Duvnjak
1. Smirčić L, Šušković T, Ferenčić Ž. Pheochromocytoma without hypertension. J Int Med 1994; 235:373-374.

2. Duvnjak M, Duvnjak L, Dodig M, Šimičević VN, Troskot B, Supanc V. Factors predictive of the healing of pancreatic pseudocysts treated by percutaneous evacuation. Hepatogastroenterology 1998;45(20): 536-40.

3. Duvnjak L, Vučković S, Car N, Metelko Ž. Relationship between autonomic function, 24-h blood pressure and albuminuria in normotensive, normoalbuminuric patients with type 1 diabetes J Diab Complic 2001; 15(6):314-319.

4. Duvnjak L, Vučković S, Pepeonik Ž, Metelko Ž. Relationship between autonomic neuropathy, 24h blood pressure and retinopathy in normoalbuminuric and normotensive type 1 diabetic patients Diab Nutr Metab 2003; 16(2):102-108.

5. Hertz M, Profozic V, Arora V, Smircic-Duvnjak L, Kovacevic I, Boras J, Campaigne N, Metelko Z. Effects of a Fixed Mixture of 25% Insulin Lispro and 75% npl ON Plasma Glucose during and after Moderate Physical Excercise in Patients with Type 2 Diabetes. Cur Med Res Opin 2002; 18(4): 188-193.

6. Smirčić- Duvnjak L, Vizner B, Koršić M, Sekso M. Diagnostic value of Thyrotropin releasing hormone test in 129 patients with suspected tumoral hyperprolactinaemia. Coll Anthropol 2002; 26(2):635-641.

7. Bulum J. Car N. Smircic-Duvnjak L. Gracin S. Metelko Z. Takayasu's arteritis and chronic autoimmune thyroiditis in a patient with type 1 diabetes mellitus. Clin Rheumatol 2005; 24(2):169-71.

8. Nemet I. Turk Z. Duvnjak L. Car N. Varga-Defterdarovic L. Humoral methylglyoxal level reflects glycemic fluctuation. Clin Bioch 2005; 38(4):379-383.

9. Duvnjak L, Pepeonik Ž, Car N, Metelko Ž.Increased night/day diastolic blood pressure ratio is associated with

high normal urinary albumin excretion and retinopathy in normotensive and normoalbuminuric type 1 diabetic patients. Diabetol Croat 2005 ; 34(2):51-57

10. Smirčić-Duvnjak L. Arterijska hipertenzija i šećerna bolest. Medix 2009; sup XV: 80-81, 45-56

11. Duvnjak L. Hypertension and the metabolic syndrome The 6th FESCC Continuous Postgraduate Course in Clinical Chemistry: New trends in diagnosis, monitorng and management of metabolic syndrome Topić E, Brguljan M P, Blaton V (ur.), Zagreb : Medicinska naklada, 2006

12. Smirčić-Duvnjak L. Patofiziologija metaboličkog sindroma. Medicus 2004; 13(2):15-25.

13 .Duvnjak M. Tomasic V. Gomercic M. Duvnjak LS. Barsic N. Lerotic I. Therapy of nonalcoholic fatty liver disease: current status. Journal of Physiology & Pharmacology. 60(Suppl 7):57-66, 2009

14.Duvnjak L. Duvnjak M. The Metabolic Syndrome - an ongoing story.Journal of Physiology & Pharmacology. 60(Suppl 7):19-24, 2009

Ureduju:

Obnovljeno 20. listopada 2006.